Boron Neutron Capture Therapy for oncology
Development of a new medical technology: accelerator-based epithermal neutron source for boron neutron capture therapy for oncological diseases Introduction of this medical technology into clinical practice in the Russian Federation
Strategic Academic Unite (SAU) in which the project is being implemented
Global scientific and technological problems to be tackled by the project
Mortality in the Russian Federation from brain tumors such as glioblastoma is estimated to 4000 cases each year. The project is oriented towards the development of a very promising therapy technology for cancer patients and especially for those suffering from aggressive forms of brain tumors, for which there is no other method of effective treatment.
Objective of the project
Development and introduction into clinical practice in the RF of the promising medical technology Boron Neutron Capture Therapy for oncological diseases (BNCT) using an accelerator-based source of epithermal neutrons of high intensity, created at the Institute of nuclear physics of the Siberian Branch of the Russian Academy of Sciences (INP SB RAS)
Expected outcomes of the project
Development of a technology for the clinical treatment of cancer, including:
• Creation of a new generation source of epithermal neutrons suitable for clinical use, conduct of clinical trials required to obtain medical license from the Ministry of Health on the use of the Boron Neutron Capture Therapy of malignant tumors;
• Development of a national synthesis technology already used (borfenilalanin) and of promising boron-containing drugs for BNCT in order to realize import substitution and increase the efficiency of treatment;
• Creation of a NSU clinic for the implementation of a BNCT pilot-project in Russia. The project has a designed capacity of 500 patients a year.
• Training of medical workers and physicists for the implementation of Bore Neutron Capture Therapy.
• Creation of a new generation source of epithermal neutrons suitable for clinical use, conduct of clinical trials required to obtain medical license from the Ministry of Health on the use of the Boron Neutron Capture Therapy of malignant tumors;
• Development of a national synthesis technology already used (borfenilalanin) and of promising boron-containing drugs for BNCT in order to realize import substitution and increase the efficiency of treatment;
• Creation of a NSU clinic for the implementation of a BNCT pilot-project in Russia. The project has a designed capacity of 500 patients a year.
• Training of medical workers and physicists for the implementation of Bore Neutron Capture Therapy.
Project's team (clue collaborators)
Partners of the project
- Budker Institute of Nuclear Physics, Siberian Branch of the Russian Academy of Sciences (SB RAS);
- Novosibirsk State Medicine University;
- N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS;
- Institute of Chemical Biology and Fundamental Medicine SB RAS;
- Federal Research Center, Institute of Cytology and Genetics SB RAS;
- Institute of molecular and cellular biology SB RAS;
- Lavrentyev Institute of Hydrodynamics of SB RAS;
- Nesmeyanov Institute of Organoelement Compounds SB RAS;
- Oxford University;
- National Research Nuclear University MEPhI;
- Tomsk National Research Medical Center RAS;
- University of Tsukuba